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KMID : 0370219970410060730
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Yakhak Hoeji
1997 Volume.41 No. 6 p.730 ~ p.736
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Body Distribution of 125I-rhEGF Across Normal and Damaged Rat Skins
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이정욱/Lee JU
정석재/이민화/심창구/Chung SJ/Lee MH/Shim CK
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Abstract
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Distribution of radioactivity in the skin tissues, subcutaneous tissues, blood and body organs was examined following topical application of 125I-rhEGF (0.4 mcCi), in the form of a Pluronic F-127 gel, on the normal and damaged (burned and stripped) skins of SD male rats. The radioactivity in the skin tissues and subcutaneous tissues was 3-5 times higher for the damaged skins than for the normal skin. But pretreatment of the skin with rhEGF (1mcg) twice at 24 hr dose intervals affected the distribution of the radioactivity yielding the order of burned skin> stripped skin=normal skin. The decrease for the stripped skin by the pretreatment might be related either to the pathophysiological change of the skin or to the down regulation of the EGF receptor. Liver showed the highest radioactivity in amount following single and multiple administration of the drug to the normal and damaged skins. But,in concentration, the kidney and stomach showed higher value than the liver which is consistent with that kidney is a major eliminating organ of EGF and that EGF exerts its pharmacological effect specifically for the stomach.
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